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Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation.

ABSTRACT: The integrity of the intestinal mucus barrier is crucial for human health, as it serves as the body's first line of defense against pathogens. However, postnatal development of the mucus barrier and interactions between maturity and its ability to adapt to external challenges in neonatal infants remain unclear. In this study, we unveil a distinct developmental trajectory of the mucus barrier in preterm piglets, leading to enhanced mucus microstructure and reduced mucus diffusivity compared to term piglets. Notably, we found that necrotizing enterocolitis (NEC) is associated with increased mucus diffusivity of our large pathogen model compound, establishing a direct link between the NEC condition and the mucus barrier. Furthermore, we observed that addition of sodium decanoate had varying effects on mucus diffusivity depending on maturity and health state of the piglets. These findings demonstrate that regulatory mechanisms governing the neonatal mucosal barrier are highly complex and are influenced by age, maturity, and health conditions. Therefore, our results highlight the need for specific therapeutic strategies tailored to each neonatal period to ensure optimal gut health.

SUBMITTER: Mortensen JS

PROVIDER: S-EPMC10985073 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation.

Mortensen Janni Støvring JS Bohr Søren S-R SS Krog Lasse Skjoldborg LS Bøtker Johan Peter JP Kapousidou Vaya V Saaby Lasse L Hatzakis Nikos S NS Mørck Nielsen Hanne H Nguyen Duc Ninh DN Rønholt Stine S

Scientific reports 20240401 1

The integrity of the intestinal mucus barrier is crucial for human health, as it serves as the body's first line of defense against pathogens. However, postnatal development of the mucus barrier and interactions between maturity and its ability to adapt to external challenges in neonatal infants remain unclear. In this study, we unveil a distinct developmental trajectory of the mucus barrier in preterm piglets, leading to enhanced mucus microstructure and reduced mucus diffusivity compared to te ...[more]

PMID: 38561398

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Dataset Information

Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation.

Publications

Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation.

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