Social relationships, amyloid burden, and dementia: The ARIC-PET study.
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ABSTRACT: Introduction
This study aimed to assess whether social relationships in mid-life reduce the risk of dementia related to amyloid burden.Methods
Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990-1992). A composite measure, "social relationships," was generated. Brain amyloid was evaluated with florbetapir positron emission tomography (PET); (visit 5; 2012-2014). Incident dementia cases were identified following visit 5 through 2019 using ongoing surveillance. Relative contributions of mid-life social relationships and elevated brain amyloid to incident dementia were evaluated with Cox regression models.Results
Among 310 participants without dementia, strong mid-life social relationships were associated independently with lower dementia risk. Elevated late-life brain amyloid was associated with greater dementia risk.Discussion
Although mid-life social relationships did not moderate the relationship between amyloid burden and dementia, these findings affirm the importance of strong social relationships as a potentially protective factor against dementia.
SUBMITTER: Groechel RC
PROVIDER: S-EPMC10988116 | biostudies-literature | 2024 Apr-Jun
REPOSITORIES: biostudies-literature
Publications
Social relationships, amyloid burden, and dementia: The ARIC-PET study.
Groechel Renée C RC Liu Albert C AC Liu Chelsea C Knopman David S DS Koton Silvia S Kucharska-Newton Anna M AM Lutsey Pamela L PL Mosley Thomas H TH Palta Priya P Sharrett A Richey AR Walker Keenan A KA Wong Dean F DF Gottesman Rebecca F RF
Alzheimer's & dementia (Amsterdam, Netherlands) 20240402 2
<h4>Introduction</h4>This study aimed to assess whether social relationships in mid-life reduce the risk of dementia related to amyloid burden.<h4>Methods</h4>Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990-1992). A composite measure, "social relationships," was generated. Brain amyloid was evaluated with florbetapir positron emission tomography (PET); (visit 5; 2012-2014). Incident dementia cases were identified ...[more]
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