Ontology highlight
ABSTRACT:
SUBMITTER: Shi J
PROVIDER: S-EPMC10989576 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Shi Jingcun J Zhang Bingqing B Wu Ziqian Z Zhang Yuhan Y Gupta Anand A Wang Xudong X Wang Jieyu J Pan Lisha L Xiao Meng M Zhang Shijian S Wang Lei L
Journal of cellular and molecular medicine 20240401 8
Sensory nerves play a crucial role in maintaining bone homeostasis by releasing Semaphorin 3A (Sema3A). However, the specific mechanism of Sema3A in regulation of bone marrow mesenchymal stem cells (BMMSCs) during bone remodelling remains unclear. The tibial denervation model was used and the denervated tibia exhibited significantly lower mass as compared to sham operated bones. In vitro, BMMSCs cocultured with dorsal root ganglion cells (DRGs) or stimulated by Sema3A could promote osteogenic di ...[more]