Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.
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ABSTRACT:
SUBMITTER: Kim W
PROVIDER: S-EPMC109902 | biostudies-literature | 1998 Aug
REPOSITORIES: biostudies-literature
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Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.
Kim W W Tang Y Y Okada Y Y Torrey T A TA Chattopadhyay S K SK Pfleiderer M M Falkner F G FG Dorner F F Choi W W Hirokawa N N Morse H C HC
Journal of virology 19980801 8
A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C terminus of a cellular protein, KIF4, a microtubule-associated motor protein that belongs to the kinesin superfamily. KIF4-MuLV Gag associations have been detected in vitro and in vivo in mammalian cells. We suggest that KIF4 could be involved in Gag polyprotein translocation from the cytoplasm to the c ...[more]
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