Dataset Information

Circulating miRNA-21 is an innovative biomarker for cardiovascular events in erectile dysfunction patients.

ABSTRACT:

Introduction

It is well-known that circulating microRNAs (miRNAs) play a relevant role in many kinds of diseases by regulating the expression of genes involved in various pathophysiologic processes, including erectile dysfunction (ED) and cardiovascular diseases (CVD).

Purpose

This study aimed to identify the miRNA-21 profile in the blood samples of patients with ED, CVD, and the combination of both pathologies to elucidate the potential function of miRNA-21.

Methods

A total of 45 patients with CVD and/or who underwent the erectile function test were included and divided into the following categories: CVD with ED (cases, n = 29) and controls (n = 16) with either ED or CVD. Real-time polymerase chain reaction analysis verified the results. miRNA-21 expression was quantified, and informatics analysis was applied to predict the functions of this differentially expressed miRNA-21.

Results

A total of 64% of cases (63 ± 9 years, 66% with severe ED, 56% with CV ejection fraction) first presented ED as the sentinel clinical manifestation. Serum miRNA-21 levels in the control ED were significant, up to 10-fold higher than in the CVD controls and cases. A significant inverse (p = 0.0368, β = -2.046) correlation was found between erectile function and miRNA-21 levels.

Conclusions

Our study provides comprehensive insights into the functional interaction between miRNA-21 and ED in CVD patients. Its relevance lies in the potential of miRNA as a biomarker to be applied in the cardiovascular predictive medicine field.

SUBMITTER: Agullo L

PROVIDER: S-EPMC10991794 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Publications

Circulating miRNA-21 is an innovative biomarker for cardiovascular events in erectile dysfunction patients.

Agulló Laura L Segura Ana A Ortuño-Miquel Samanta S Brinca Ana Teresa AT Micol-Ponce Rosa R Arrarte Vicente V Ponce María Rosa MR Miró-Martínez Pau P Zandonai Thomas T Peiró Ana M AM

Frontiers in cardiovascular medicine 20240321

<h4>Introduction</h4>It is well-known that circulating microRNAs (miRNAs) play a relevant role in many kinds of diseases by regulating the expression of genes involved in various pathophysiologic processes, including erectile dysfunction (ED) and cardiovascular diseases (CVD).<h4>Purpose</h4>This study aimed to identify the miRNA-21 profile in the blood samples of patients with ED, CVD, and the combination of both pathologies to elucidate the potential function of miRNA-21.<h4>Methods</h4>A tota ...[more]

PMID: 38576420

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Project description:BackgroundCardiovascular diseases (CVDs) and erectile dysfunction (ED) frequently co-occur, significantly affecting the quality of life of individuals.AimTo assess the impact of cardiac rehabilitation (CR) on ED in patients with CVD through a systematic review and meta-analysis.MethodsThis study analyzed randomized controlled trials and other studies comparing CR with usual care for adult males (≥18 years) with any cardiac disease. Literature searches were extensive, and the risk of bias was evaluated by the Cochrane Collaboration tool. Data from 6 studies involving 668 participants were included in the meta-analysis.OutcomesThe primary outcome was the improvement in ED, as measured with the International Index of Erectile Function.ResultsA statistically significant improvement in erectile function was observed across 6 studies, with a Morris dppc2 effect size of 0.38 (95% CI, 0.17-0.59). Despite initial high heterogeneity (I 2 = 95.7%), identification and correction for selective outcome reporting bias mitigated this issue.Clinical translationCR has a modest but statistically significant impact on improving ED in patients with CVD, indicating its potential positive contribution to the quality of life of this group.Strengths and limitationsThe study's strengths include a comprehensive literature search and a rigorous methodological approach. Limitations involve high heterogeneity among studies and a low level of evidence due to small sample sizes and study quality; however, the source of heterogeneity was identified and mitigated following risk-of-bias assessment.ConclusionThe results suggest that CR has a statistically significant but modest impact on improving ED in patients with CVD. Clinicians should consider the integration of CR into the clinical management of these individuals. This study underscores the potential for CR to contribute positively to the quality of life for patients with CVD by addressing associated ED (PROSPERO: CRD42022374625).

Dataset Information

Circulating miRNA-21 is an innovative biomarker for cardiovascular events in erectile dysfunction patients.

Introduction

Purpose

Methods

Results

Conclusions

Publications

Circulating miRNA-21 is an innovative biomarker for cardiovascular events in erectile dysfunction patients.

Similar Datasets

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