Ontology highlight
ABSTRACT: Background
The 2021 World Health Organization Classification of Central Nervous System Tumors updates glioma subtyping and grading system, and incorporates EGFR amplification (Amp) as one of diagnostic markers for glioblastoma (GBM).Purpose
This study aimed to describe the frequency, clinical value and molecular correlation of EGFR Amp in diffuse gliomas based on the latest classification.Methods
We reviewed glioma patients between 2011 and 2022 at our hospital, and included 187 adult glioma patients with available tumor tissue for detection of EGFR Amp and other 59 molecular markers of interest. Clinical, radiological and pathological data was analyzed based on the status of EGFR Amp in different glioma subtypes.Results
163 gliomas were classified as adult-type diffuse gliomas, and the number of astrocytoma, oligodendroglioma and GBM was 41, 46, and 76. EGFR Amp was more common in IDH-wildtype diffuse gliomas (66.0%) and GBM (85.5%) than IDH-mutant diffuse gliomas (32.2%) and its subtypes (astrocytoma, 29.3%; oligodendroglioma, 34.8%). EGFR Amp did not stratify overall survival (OS) in IDH-mutant diffuse gliomas and astrocytoma, while was significantly associated with poorer OS in IDH-wildtype diffuse gliomas, histologic grade 2 and 3 IDH-wildtype diffuse astrocytic gliomas and GBM.Conclusion
Our study validated EGFR Amp as a diagnostic marker for GBM and still a useful predictor for shortened OS in this group.
SUBMITTER: Wang H
PROVIDER: S-EPMC11002900 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
Wang Hai H Zhang Xin X Liu Jiahui J Chen Wenlin W Guo Xiaopeng X Wang Yaning Y Wang Yuekun Y Xing Hao H Liang Tingyu T Shi Yixin Y Liu Delin D Yang Tianrui T Xia Yu Y Li Junlin J Wu Jiaming J Liu Qianshu Q Qu Tian T Guo Siying S Li Huanzhang H Zhang Kun K Li Yilin Y Jin Shanmu S Zhao Dachun D Wang Yu Y Ma Wenbin W
Frontiers in neuroscience 20240226
<h4>Background</h4>The 2021 World Health Organization Classification of Central Nervous System Tumors updates glioma subtyping and grading system, and incorporates <i>EGFR</i> amplification (Amp) as one of diagnostic markers for glioblastoma (GBM).<h4>Purpose</h4>This study aimed to describe the frequency, clinical value and molecular correlation of <i>EGFR</i> Amp in diffuse gliomas based on the latest classification.<h4>Methods</h4>We reviewed glioma patients between 2011 and 2022 at our hospi ...[more]