Dataset Information

Observations of cold-induced vasodilation in persons with spinal cord injuries.

ABSTRACT:

Study design

Acute experimental study.

Objectives

Cold-induced vasodilation is a local mechanism of protection against frostbite in non-injured persons. We assessed whether an increase in skin blood flow (SkBF) during local cooling (LC) was observed in individuals with spinal cord injuries (SCIs) and if the response patterns differed between region levels or sites.

Setting

Laboratory of Wakayama Medical University and the affiliated clinics, Japan.

Methods

A local cooler device (diameter 4 cm) was placed on the chest (sensate) and right thigh (non-sensate) in persons with cervical (SCI_C; n = 9) and thoracolumbar SCIs (SCI_TL; n = 9). After the surface temperature under the device was controlled at 33 °C for 10 min (baseline), LC (-0.045 °C/s) was applied and the skin temperature was maintained at 15 and 8 °C for 15 min of each stage. SkBF (laser Doppler flowmetry) was monitored using a 1-mm needle-type probe inserted into its center.

Results

The percent change in SkBF (%ΔSkBF) on the chest remained unchanged until the end of 15 °C stage; thereafter, it increased to a level at least 70% greater than the baseline during the 8 °C stage in both groups. The %ΔSkBF on the thigh in both SCI_C and SCI_TL notably increased from 8 and 6 min respectively, during the 8°C stage, compared to 1 min before the stage; however, it did not exceed the baseline level.

Conclusions

An increase in SkBF during LC was observed both in the sensate and non-sensate areas in SCIs, although the magnitude was larger in the sensate area.

SUBMITTER: Fujita Y

PROVIDER: S-EPMC11003866 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Publications

Observations of cold-induced vasodilation in persons with spinal cord injuries.

Fujita Yasuhisa Y Kamijo Yoshi-Ichiro YI Kinoshita Tokio T Hashizaki Takamasa T Murai Kouta K Yoshikawa Tatsuya T Umemoto Yasunori Y Kaminaka Chikako C Shibasaki Manabu M Tajima Fumihiro F Nishimura Yukihide Y

Spinal cord 20240222 4

<h4>Study design</h4>Acute experimental study.<h4>Objectives</h4>Cold-induced vasodilation is a local mechanism of protection against frostbite in non-injured persons. We assessed whether an increase in skin blood flow (SkBF) during local cooling (LC) was observed in individuals with spinal cord injuries (SCIs) and if the response patterns differed between region levels or sites.<h4>Setting</h4>Laboratory of Wakayama Medical University and the affiliated clinics, Japan.<h4>Methods</h4>A local co ...[more]

PMID: 38388759

Similar Datasets

Project description:BackgroundRollover crashes continue to be a substantial public health issue in North America. Previous research has shown that the cervical spine is the most injured spine segment in rollovers, but much of the past research has focused on risk factors rather than the actual cervical spine injuries. We sought to examine how different types of cervical spine injuries (vertebral and/or cord injury) vary with different occupant-related factors in rollovers and to compare these with non-rollovers.MethodsWe obtained crash and injury information from the National Automotive Sampling System-Crashworthiness Data System (NASS-CDS) for 2005-2015 and Crash Investigation Sampling System (CISS) for 2017-2022. Based on weighted data, we calculated relative risks to assess how occupant sex, seat belt use, ejection status, and fatal outcome relate to the rate of different cervical spine injuries in rollovers and non-rollovers.ResultsIn NASS-CDS occupants with cervical spine injuries (N = 111,040 weighted cases), about 91.5% experienced at least one vertebral injury whereas only 11.3% experienced a spinal cord injury (most of which had a concomitant vertebral fracture). All types of cervical spine injuries we examined were 3.4-5.2 times more likely to occur in rollovers compared to non-rollovers. These relative risks were similar for both sexes, belted and unbelted, non-ejected, and non-fatal occupants. The number of weighted CISS occupants with cervical spine injuries (N = 42,003) was smaller than in the NASS analysis, but cervical spine injuries remained 6.25 to 6.36 times more likely in rollovers compared to non-rollovers despite a more modern vehicle fleet.ConclusionsThese findings underscore the continued need for rollover-specific safety countermeasures, especially those focused on cervical spine injury prevention, and elucidate the frequency, severity and other characteristics of the specific vertebral and spinal cord injuries being sustained in rollovers. Our findings suggest that countermeasures focused on preventing cervical vertebral fractures will also effectively prevent most cervical spinal cord injuries.

Dataset Information

Observations of cold-induced vasodilation in persons with spinal cord injuries.

Study design

Objectives

Setting

Methods

Results

Conclusions

Publications

Observations of cold-induced vasodilation in persons with spinal cord injuries.

Similar Datasets

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