Mortality among human immunodeficiency virus type 2-positive villagers in rural Guinea-Bissau is correlated with viral genotype.
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ABSTRACT:
SUBMITTER: Grassly NC
PROVIDER: S-EPMC110115 | biostudies-literature | 1998 Oct
REPOSITORIES: biostudies-literature
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Mortality among human immunodeficiency virus type 2-positive villagers in rural Guinea-Bissau is correlated with viral genotype.
Grassly N C NC Xiang Z Z Ariyoshi K K Aaby P P Jensen H H Schim van der Loeff M M Dias F F Whittle H H Breuer J J
Journal of virology 19981001 10
We present the results of a 6-year study of 131 human immunodeficiency virus (HIV) type 2 (HIV-2)-infected individuals from a rural population in Guinea-Bissau. Proviral DNA sequences 1.3 kb in length were obtained from each individual and, together with clinical data, including proviral load and CD4 and CD8 levels, were used to assess whether viral genotype influences clinical outcome. With a phylogenetic model, a correlation was found between viral genotype and mortality; this correlation was ...[more]
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