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The optimal glycemic target in critically ill patients: an updated network meta-analysis.


ABSTRACT: Acute glycemic control significantly affects the clinical outcomes of critically ill patients. This updated network meta-analysis examines the benefits and harms of four target blood glucose levels (< 110, 110-144, 144-180, and > 180 mg/dL). Analyzing data of 27,541 patients from 37 trials, the surface under the cumulative ranking curve for mortality and hypoglycemia was highest at a target blood glucose level of 144-180 mg/dL, while for infection and acute kidney injury at 110-144 mg/dL. Further evidence is needed to determine whether 110-144 or 144-180 mg/dL is superior as an optimal glucose target, considering prioritized outcomes.

SUBMITTER: Tanaka A 

PROVIDER: S-EPMC11017653 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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The optimal glycemic target in critically ill patients: an updated network meta-analysis.

Tanaka Aiko A   Yatabe Tomoaki T   Suhara Tomohiro T   Egi Moritoki M  

Journal of intensive care 20240414 1


Acute glycemic control significantly affects the clinical outcomes of critically ill patients. This updated network meta-analysis examines the benefits and harms of four target blood glucose levels (< 110, 110-144, 144-180, and > 180 mg/dL). Analyzing data of 27,541 patients from 37 trials, the surface under the cumulative ranking curve for mortality and hypoglycemia was highest at a target blood glucose level of 144-180 mg/dL, while for infection and acute kidney injury at 110-144 mg/dL. Furthe  ...[more]

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