Ontology highlight
ABSTRACT:
SUBMITTER: Pollex T
PROVIDER: S-EPMC11018526 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Pollex Tim T Rabinowitz Adam A Gambetta Maria Cristina MC Marco-Ferreres Raquel R Viales Rebecca R RR Jankowski Aleksander A Schaub Christoph C Furlong Eileen E M EEM
Nature genetics 20240311 4
To regulate expression, enhancers must come in proximity to their target gene. However, the relationship between the timing of enhancer-promoter (E-P) proximity and activity remains unclear, with examples of uncoupled, anticorrelated and correlated interactions. To assess this, we selected 600 characterized enhancers or promoters with tissue-specific activity in Drosophila embryos and performed Capture-C in FACS-purified myogenic or neurogenic cells during specification and tissue differentiatio ...[more]