Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto A
PROVIDER: S-EPMC110738 | biostudies-literature | 2000 Sep
REPOSITORIES: biostudies-literature
Yamamoto A A Schofield M J MJ Biswas I I Hsieh P P
Nucleic acids research 20000901 18
The MutS family of DNA repair proteins recognizes base pair mismatches and insertion/deletion mismatches and targets them for repair in a strand-specific manner. Photocrosslinking and mutational studies previously identified a highly conserved Phe residue at the N-terminus of Thermus aquaticus MutS protein that is critical for mismatch recognition in vitro. Here, a mutant Escherichia coli MutS protein harboring a substitution of Ala for the corresponding Phe36 residue is assessed for proficiency ...[more]