Ontology highlight
ABSTRACT:
SUBMITTER: Tsuno A
PROVIDER: S-EPMC110823 | biostudies-literature | 2000 Mar
REPOSITORIES: biostudies-literature
Tsuno A A Miyoshi K K Tsujii R R Miyakawa T T Mizuta K K
Molecular and cellular biology 20000301 6
A secretory defect causes specific and significant transcriptional repression of both ribosomal protein and rRNA genes (K. Mizuta and J. R. Warner, Mol. Cell. Biol. 14:2493-2502, 1994), suggesting the coupling of plasma membrane and ribosome syntheses. In order to elucidate the molecular mechanism of the signaling pathway, we isolated a cold-sensitive mutant with a mutation in a gene termed RRS1 (regulator of ribosome synthesis), which appeared to be defective in the signaling pathway. The rrs1- ...[more]