Ontology highlight
ABSTRACT:
SUBMITTER: Maillard AP
PROVIDER: S-EPMC1112068 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Maillard Antoine P AP Biarrotte-Sorin Sabrina S Villet Régis R Mesnage Stéphane S Bouhss Ahmed A Sougakoff Wladimir W Mayer Claudine C Arthur Michel M
Journal of bacteriology 20050601 11
Weissella viridescens FemX (FemX(Wv)) belongs to the Fem family of nonribosomal peptidyl transferases that use aminoacyl-tRNA as the amino acid donor to synthesize the peptide cross-bridge found in the peptidoglycan of many species of pathogenic gram-positive bacteria. We have recently solved the crystal structure of FemX(Wv) in complex with the peptidoglycan precursor UDP-MurNAc-pentapeptide and report here the site-directed mutagenesis of nine residues located in the binding cavity for this su ...[more]