CHOGlycoNET: Comprehensive glycosylation reaction network for CHO cells.
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ABSTRACT:
SUBMITTER: Kotidis P
PROVIDER: S-EPMC11132536 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Publications
CHOGlycoNET: Comprehensive glycosylation reaction network for CHO cells.
Kotidis Pavlos P Donini Roberto R Arnsdorf Johnny J Hansen Anders Holmgaard AH Voldborg Bjørn Gunnar Rude BGR Chiang Austin W T AWT Haslam Stuart M SM Betenbaugh Michael M Jimenez Del Val Ioscani I Lewis Nathan E NE Krambeck Frederick F Kontoravdi Cleo C
Metabolic engineering 20230104
Chinese hamster ovary (CHO) cells are extensively used for the production of glycoprotein therapeutics proteins, for which N-linked glycans are a critical quality attribute due to their influence on activity and immunogenicity. Manipulation of protein glycosylation is commonly achieved through cell or process engineering, which are often guided by mathematical models. However, each study considers a unique glycosylation reaction network that is tailored around the cell line and product at hand. ...[more]
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