Brain clearance is reduced during sleep and anesthesia.
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ABSTRACT:
SUBMITTER: Miao A
PROVIDER: S-EPMC11156584 | biostudies-literature | 2024 Jun
REPOSITORIES: biostudies-literature
Publications
Brain clearance is reduced during sleep and anesthesia.
Miao Andawei A Luo Tianyuan T Hsieh Bryan B Edge Christopher J CJ Gridley Morgan M Wong Ryan Tak Chun RTC Constandinou Timothy G TG Wisden William W Franks Nicholas P NP
Nature neuroscience 20240513 6
It has been suggested that the function of sleep is to actively clear metabolites and toxins from the brain. Enhanced clearance is also said to occur during anesthesia. Here, we measure clearance and movement of fluorescent molecules in the brains of male mice and show that movement is, in fact, independent of sleep and wake or anesthesia. Moreover, we show that brain clearance is markedly reduced, not increased, during sleep and anesthesia. ...[more]
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