Ontology highlight
ABSTRACT:
SUBMITTER: Lorenzo-Sanz L
PROVIDER: S-EPMC11196727 | biostudies-literature | 2024 Jun
REPOSITORIES: biostudies-literature
Lorenzo-Sanz Laura L Lopez-Cerda Marta M da Silva-Diz Victoria V Artés Marta H MH Llop Sandra S Penin Rosa M RM Bermejo Josep Oriol JO Gonzalez-Suarez Eva E Esteller Manel M Viñals Francesc F Espinosa Enrique E Oliva Marc M Piulats Josep M JM Martin-Liberal Juan J Muñoz Purificación P
Nature communications 20240624 1
Immune checkpoint blockade (ICB) approaches have changed the therapeutic landscape for many tumor types. However, half of cutaneous squamous cell carcinoma (cSCC) patients remain unresponsive or develop resistance. Here, we show that, during cSCC progression in male mice, cancer cells acquire epithelial/mesenchymal plasticity and change their immune checkpoint (IC) ligand profile according to their features, dictating the IC pathways involved in immune evasion. Epithelial cancer cells, through t ...[more]