Ontology highlight
ABSTRACT:
SUBMITTER: Lu R
PROVIDER: S-EPMC11199980 | biostudies-literature | 2024 Jun
REPOSITORIES: biostudies-literature
Lu Ruipeng R Hong Jingjing J Fu Tong T Zhu Yu Y Tong Ruiqi R Ai Di D Wang Shuai S Huang Qingsong Q Chen Ceshi C Zhang Zhiming Z Zhang Rui R Guo Huiling H Li Boan B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20240416 24
Triple-negative breast cancer (TNBC), the most aggressive subtype of breast cancer, has a poor prognosis and lacks effective treatment strategies. Here, the study discovered that TNBC shows a decreased expression of epithelial transcription factor ovo-like 2 (OVOL2). The loss of OVOL2 promotes fatty acid oxidation (FAO), providing additional energy and NADPH to sustain stemness characteristics, including sphere-forming capacity and tumor initiation. Mechanistically, OVOL2 not only suppressed STA ...[more]