Dataset Information

Association of α-HBDH levels with the severity and recurrence after acute ischemic stroke.

ABSTRACT:

Objective

α-HBDH serves as a biomarker of myocardial damage and is implicated in adverse outcomes across various critical illnesses. Our study aimed to assess the correlation between α-HBDH levels, and severity and recurrence of acute ischemic stroke (AIS).

Methods

We enrolled patients with mild-to-moderate AIS within 72 h of onset. Based on the baseline score of the National Institutes of Health Stroke Scale (bNIHSS) at registration, patients were categorized into mild (bNIHSS ≤ 4 points) and moderate AIS groups (4 < bNIHSS ≤ 10 points). Subsequently, based on the normal upper limit of α-HBDH, patients were divided into low-level α-HBDH (≤ 180 U/L) and high-level α-HBDH (> 180 U/L) groups. Multivariate logistic regression analysis and Cox proportional hazard regression analysis were employed to evaluate the relationship between α-HBDH levels and bNIHSS scores as well as the risk of recurrent AIS within 90 days.

Results

We observed a significant association between higher baseline levels of α-HBDH and increased bNIHSS scores, indicating a more severe AIS (odds ratio = 24.449; 95% confidence interval [CI], 8.749-68.324; p < 0.01). Additionally, the risk of recurrent AIS within 90 days was 4.666 times higher in the high-level α-HBDH group compared to the low-level group (hazard ratio = 4.666; 95% CI, 2.481-8.777; p < 0.01).

Conclusions

The baseline level of α-HBDH is significantly correlated with the severity of AIS and the risk of recurrent AIS within 90 days.

SUBMITTER: Wang Q

PROVIDER: S-EPMC11201310 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature

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Publications

Association of α-HBDH levels with the severity and recurrence after acute ischemic stroke.

Wang Qiang Q Deng Ting T Xie Yuanyuan Y Lu Haitao H Zhang Tong T Gao Daiquan D

European journal of medical research 20240626 1

<h4>Objective</h4>α-HBDH serves as a biomarker of myocardial damage and is implicated in adverse outcomes across various critical illnesses. Our study aimed to assess the correlation between α-HBDH levels, and severity and recurrence of acute ischemic stroke (AIS).<h4>Methods</h4>We enrolled patients with mild-to-moderate AIS within 72 h of onset. Based on the baseline score of the National Institutes of Health Stroke Scale (bNIHSS) at registration, patients were categorized into mild (bNIHSS ≤ ...[more]

PMID: 38926868

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Dataset Information

Association of α-HBDH levels with the severity and recurrence after acute ischemic stroke.

Objective

Methods

Results

Conclusions

Publications

Association of α-HBDH levels with the severity and recurrence after acute ischemic stroke.

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