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ABSTRACT: Background
Foslevodopa/foscarbidopa is a subcutaneous infusion of levodopa/carbidopa prodrugs.Objectives
Assess correlations between sleep and efficacy from interim data of a phase 3 trial of foslevodopa/foscarbidopa (NCT03781167).Methods
Pearson correlations between sleep (Parkinson's Disease Sleep Scale-2 [PDSS-2]) and quality of life (QoL; Parkinson's Disease Questionnaire-39), motor experiences of daily living (m-EDL; Movement Disorder Society-Unified Parkinson's Disease Scale Part II), and "Off"/"On" times were calculated for baseline and week 26 improvements. Regression analyses were adjusted for baseline PDSS-2 score.Results
Baseline sleep correlated moderately with QoL (r = 0.44, P < 0.001) and weakly with m-EDL (r = 0.28; P < 0.001). Sleep improvement weakly correlated with improved "Off" time (r = 0.37; P < 0.001) and QoL (r = 0.36; P < 0.001). Regression analyses demonstrated significant positive associations for improved sleep, "Off" time, QoL, and m-EDL.Conclusions
Improved sleep with foslevodopa/foscarbidopa was associated with improved QoL and "Off" time.
SUBMITTER: Chaudhuri KR
PROVIDER: S-EPMC11233834 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Chaudhuri K Ray KR Facheris Maurizio F MF Bergmans Bruno B Bergquist Filip F Criswell Susan R SR Jia Jia J Kukreja Pavnit P Mukai Yohei Y Spiegel Amy M AM Gupta Resmi R Bergmann Lars L Pahwa Rajesh R
Movement disorders clinical practice 20240311 7
<h4>Background</h4>Foslevodopa/foscarbidopa is a subcutaneous infusion of levodopa/carbidopa prodrugs.<h4>Objectives</h4>Assess correlations between sleep and efficacy from interim data of a phase 3 trial of foslevodopa/foscarbidopa (NCT03781167).<h4>Methods</h4>Pearson correlations between sleep (Parkinson's Disease Sleep Scale-2 [PDSS-2]) and quality of life (QoL; Parkinson's Disease Questionnaire-39), motor experiences of daily living (m-EDL; Movement Disorder Society-Unified Parkinson's Dise ...[more]