Unknown

Dataset Information

0

Comparison of long-term clinical outcomes of bioabsorbable polymer versus durable polymer drug-eluting stents: a systematic review and meta-analysis.


ABSTRACT:

Background

One million individuals in the USA die from acute myocardial infarction (MI), which currently affects 3 million people globally. The available data about the early and late outcomes of both biodegradable polymer drug-eluting stents (BP-DES) and durable polymer drug-eluting stents exhibit inconsistency. We performed a meta-analysis comparing the safety and efficacy of BP-DES with DP-DES.

Methods

PubMed, Google Scholar, EMBASE, Cochrane, Ovid Medline, and Clinical Trials.gov databases were used to find out studies comparing BP-DES to DP-DES. All the analyses used the random-effects model.

Results

A total of 18 studies were incorporated in this meta-analysis that involved 28,874 patients, out of which 11,997 received the BP Stent, and the rest of 16,578 received the DP stent. Thorough analyses revealed that the risk of all-cause death was significantly higher in the BP-DES group (5.4% vs 2.7%) (RR 1.22, p 0.02) for two years or less than two-year follow-up. For studies with more than two years of follow-up, all-cause death was 9.07% (599/6603) in BP-DES and 9.47% (531/5602) in the DP-DES group but failed to achieve statistically significant levels (RR 0.97, p 0.58).

Conclusions

The study revealed no clinically significant (P value was > 0.05) differences in all-cause death, cardiac death, target lesion revascularization (TLR), late stent thrombosis, device-oriented composite endpoint/target lesion failure (DOCE/TLF), myocardial infarction (MI), target vessel MI, target vessel revascularization (TVR), target vessel infarction (TVI) between BP-DES and DP-DES for more than two years of follow-up. Additionally, all-cause death was only outcomes which found to have a statistically significant difference for less than two years of follow-up, while remaining were statistically non-significant.

SUBMITTER: Rehman A 

PROVIDER: S-EPMC11236827 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Comparison of long-term clinical outcomes of bioabsorbable polymer versus durable polymer drug-eluting stents: a systematic review and meta-analysis.

Rehman Abdur A   Ahmed Ifra Eeman IE   Nouman Ahmed A   Irfan Rabia R   Rehman Qareeha Q   Syed Abdul Rehman Shah ARS   Zakir Syeda Javeria SJ   Mehdi Samar S   Khosa Maha Mushtaq MM   Kumar Satesh S   Khatri Mahima M   Samiullah F N U FNU   Mohamad Tamam T   Varrassi Giustino G  

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology 20240710 1


<h4>Background</h4>One million individuals in the USA die from acute myocardial infarction (MI), which currently affects 3 million people globally. The available data about the early and late outcomes of both biodegradable polymer drug-eluting stents (BP-DES) and durable polymer drug-eluting stents exhibit inconsistency. We performed a meta-analysis comparing the safety and efficacy of BP-DES with DP-DES.<h4>Methods</h4>PubMed, Google Scholar, EMBASE, Cochrane, Ovid Medline, and Clinical Trials.  ...[more]

Similar Datasets

| S-EPMC10716332 | biostudies-literature
| S-EPMC11877205 | biostudies-literature
| S-EPMC3823917 | biostudies-literature
| S-EPMC5452149 | biostudies-literature
| S-EPMC3898413 | biostudies-literature
| S-EPMC7552849 | biostudies-literature
| S-EPMC5552220 | biostudies-literature
| S-EPMC9098972 | biostudies-literature
| S-EPMC9900447 | biostudies-literature
| S-EPMC6485796 | biostudies-literature