Ontology highlight
ABSTRACT: Importance
Paeniclostridium sordellii and Clostridioides difficile infections often cause hemorrhage in the affected tissues and organs, which is mainly attributed to their hemorrhagic toxins, TcsH and TcdA. In this study, we demonstrate that TcsH and TcdA, but not other related toxins. including Clostridioides difficile toxin B and TcsL, induce severe hepatic hemorrhage in mice. We further determine that a small region in TcsH and TcdA is critical for the hemorrhagic toxicity but not cytotoxicity or lethality of these toxins. Based on these results, we propose that the hemorrhagic toxicity of TcsH and TcdA is due to an uncharacterized mechanism, such as the presence of an unknown receptor, and future studies to identify the interactive host factors are warranted.
SUBMITTER: Zheng Y
PROVIDER: S-EPMC11237598 | biostudies-literature | 2024 Jun
REPOSITORIES: biostudies-literature
Zheng Yangling Y Yang Qi Q Luo Jianhua J Zhang Yuanyuan Y Li Xingxing X He Liuqing L Ma Chao C Tao Liang L
Microbiology spectrum 20240506 6
<i>Paeniclostridium sordellii</i> hemorrhagic toxin (TcsH) and <i>Clostridioides difficile</i> toxin A (TcdA) are two major members of the large clostridial toxin (LCT) family. These two toxins share ~87% similarity and are known to cause severe hemorrhagic pathology in animals. Yet, the pathogenesis of their hemorrhagic toxicity has been mysterious for decades. Here, we examined the liver injury after systemic exposure to different LCTs and found that only TcsH and TcdA induce overt hepatic hem ...[more]