Ontology highlight
ABSTRACT:
SUBMITTER: Thongpon P
PROVIDER: S-EPMC11239878 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Thongpon Phonpilas P Intuyod Kitti K Chomwong Sasitorn S Pongking Thatsanapong T Klungsaeng Sirinapha S Muisuk Kanha K Charoenram Naruechar N Sitthirach Chutima C Thanan Raynoo R Pinlaor Porntip P Pinlaor Somchai S
Scientific reports 20240711 1
Cholangiocarcinoma (CCA) is often diagnosed late, leading to incomplete tumor removal, drug resistance and reduced chemotherapy efficacy. Curcumin has the potential for anti-cancer activity through various therapeutic properties and can improve the efficacy of chemotherapy. We aimed to investigate the synergistic effect of a combination of curcumin and gemcitabine against CCA, targeting the LAT2/glutamine pathway. This combination synergistically suppressed proliferation in gemcitabine-resistant ...[more]