Dataset Information

Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease.

ABSTRACT:

Introduction

Altered immune signatures are emerging as a central theme in neurodegenerative disease, yet little is known about immune responses in early-onset Alzheimer's disease (EOAD).

Methods

We examined single-cell RNA-sequencing (scRNA-seq) data from peripheral blood mononuclear cells (PBMCs) and droplet digital polymerase chain reaction (ddPCR) data from CD4 T cells from participants with EOAD and clinically normal controls.

Results

We analyzed PBMCs from 16 individuals by scRNA-seq and discovered increased interferon signaling-associated gene (ISAG) expression and striking expansion of antiviral-like ISAG^hi T cells in EOAD. Isolating CD4 T cells from 19 individuals, including four cases analyzed by scRNA-seq, we confirmed increased expression of ISAG^hi marker genes. Publicly available cerebrospinal fluid leukocyte scRNA-seq data from late-onset mild cognitive impairment and AD also revealed increased expression of interferon-response genes.

Discussion

Antiviral-like ISAG^hi T cells are expanded in EOAD. Additional research into these cells and the role of heightened peripheral IFN signaling in neurodegeneration is warranted.

Highlights

Interferon-responsive T cells expanded in early-onset Alzheimer's disease (AD). Increased interferon-associated gene expression present in early- and late-onset AD. Peripheral immune changes in T and NK cells driven by females with early-onset AD.

SUBMITTER: Sirkis DW

PROVIDER: S-EPMC11247696 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature

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Publications

Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease.

Sirkis Daniel W DW Warly Solsberg Caroline C Johnson Taylor P TP Bonham Luke W LW Oddi Alexis P AP Geier Ethan G EG Miller Bruce L BL Rabinovici Gil D GD Yokoyama Jennifer S JS

Alzheimer's & dementia : the journal of the Alzheimer's Association 20240603 7

<h4>Introduction</h4>Altered immune signatures are emerging as a central theme in neurodegenerative disease, yet little is known about immune responses in early-onset Alzheimer's disease (EOAD).<h4>Methods</h4>We examined single-cell RNA-sequencing (scRNA-seq) data from peripheral blood mononuclear cells (PBMCs) and droplet digital polymerase chain reaction (ddPCR) data from CD4 T cells from participants with EOAD and clinically normal controls.<h4>Results</h4>We analyzed PBMCs from 16 individua ...[more]

PMID: 38829682

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Dataset Information

Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease.

Introduction

Methods

Results

Discussion

Highlights

Publications

Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease.

Similar Datasets

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