Ontology highlight
ABSTRACT:
SUBMITTER: Wilson MP
PROVIDER: S-EPMC11250103 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Wilson Matthew P MP Kentache Takfarinas T Althoff Charlotte R CR Schulz Céline C de Bettignies Geoffroy G Mateu Cabrera Gisèle G Cimbalistiene Loreta L Burnyte Birute B Yoon Grace G Costain Gregory G Vuillaumier-Barrot Sandrine S Cheillan David D Rymen Daisy D Rychtarova Lucie L Hansikova Hana H Bury Marina M Dewulf Joseph P JP Caligiore Francesco F Jaeken Jaak J Cantagrel Vincent V Van Schaftingen Emile E Matthijs Gert G Foulquier François F Bommer Guido T GT
Cell 20240530 14
Dolichol is a lipid critical for N-glycosylation as a carrier for activated sugars and nascent oligosaccharides. It is commonly thought to be directly produced from polyprenol by the enzyme SRD5A3. Instead, we found that dolichol synthesis requires a three-step detour involving additional metabolites, where SRD5A3 catalyzes only the second reaction. The first and third steps are performed by DHRSX, whose gene resides on the pseudoautosomal regions of the X and Y chromosomes. Accordingly, we repo ...[more]