Metabolic imaging across scales reveals distinct prostate cancer phenotypes.
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ABSTRACT:
SUBMITTER: Sushentsev N
PROVIDER: S-EPMC11252279 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Publications
Metabolic imaging across scales reveals distinct prostate cancer phenotypes.
Sushentsev Nikita N Hamm Gregory G Flint Lucy L Birtles Daniel D Zakirov Aleksandr A Richings Jack J Ling Stephanie S Tan Jennifer Y JY McLean Mary A MA Ayyappan Vinay V Horvat Menih Ines I Brodie Cara C Miller Jodi L JL Mills Ian G IG Gnanapragasam Vincent J VJ Warren Anne Y AY Barry Simon T ST Goodwin Richard J A RJA Barrett Tristan T Gallagher Ferdia A FA
Nature communications 20240716 1
Hyperpolarised magnetic resonance imaging (HP-<sup>13</sup>C-MRI) has shown promise as a clinical tool for detecting and characterising prostate cancer. Here we use a range of spatially resolved histological techniques to identify the biological mechanisms underpinning differential [1-<sup>13</sup>C]lactate labelling between benign and malignant prostate, as well as in tumours containing cribriform and non-cribriform Gleason pattern 4 disease. Here we show that elevated hyperpolarised [1-<sup>13 ...[more]
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