Ontology highlight
ABSTRACT:
SUBMITTER: Kullmer F
PROVIDER: S-EPMC11256906 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Küllmer Florian F Vepřek Nynke A NA Borowiak Malgorzata M Nasufović Veselin V Barutzki Sebastian S Thorn-Seshold Oliver O Arndt Hans-Dieter HD Trauner Dirk D
Angewandte Chemie (International ed. in English) 20221026 48
The natural product jasplakinolide is widely used to stabilize F-actin. Based on extensive structure-activity relationship studies, we have developed a new generation of photoswitchable jasplakinolides that feature rationally designed red-shifted azobenzene photoswitches. Our lead compound, nOJ, can be activated with longer wavelengths in the visible range (e.g. 440-475 nm) and rapidly returns to its inactive state through thermal relaxation. nOJ enables the reversible control of F-actin dynamic ...[more]