Ontology highlight
ABSTRACT:
SUBMITTER: Hubalek F
PROVIDER: S-EPMC11271312 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Hubálek František F Cramer Christian N CN Helleberg Hans H Johansson Eva E Nishimura Erica E Schluckebier Gerd G Steensgaard Dorte Bjerre DB Sturis Jeppe J Kjeldsen Thomas B TB
Nature communications 20240720 1
Insulin icodec is a once-weekly insulin analogue that has a long half-life of approximately 7 days, making it suitable for once weekly dosing. The Insulin icodec molecule was developed based on the hypothesis that lowering insulin receptor affinity and introducing a strong albumin-binding moiety would result in a long insulin half-life, provided that non-receptor-mediated clearance is diminished. Here, we report an insulin clearance mechanism, resulting in the splitting of insulin molecules into ...[more]