Ontology highlight
ABSTRACT:
SUBMITTER: Johnnidis JB
PROVIDER: S-EPMC1129145 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Johnnidis Jonathan B JB Venanzi Emily S ES Taxman Debra J DJ Ting Jenny P-Y JP Benoist Christophe O CO Mathis Diane J DJ
Proceedings of the National Academy of Sciences of the United States of America 20050509 20
Autoimmune regulator (aire) is a transcription factor that controls the self-reactivity of the T cell repertoire. Although previous results indicate that it exerts this function in part by promoting ectopic expression of a battery of peripheral-tissue antigens in epithelial cells of the thymic medulla, recent data argue for additional roles in negative selection of thymocytes by medullary cells. As one approach to exploring such roles, we performed computational analyses of microarray data on me ...[more]