Unknown

Dataset Information

0

Causal Association Analysis of Periodontitis and Inflammatory Bowel Disease: A Bidirectional Mendelian Randomization Study.


ABSTRACT:

Background

Periodontitis has been reported to be associated with inflammatory bowel disease (IBD), including ulcerative colitis (UC), and Crohn's disease (CD). However, the causality of these 2 diseases remains unclear. We conducted bidirectional Mendelian randomization (MR) to investigate the causal relationship between periodontitis and IBD.

Methods

We obtained the genome-wide association study (GWAS) summary data of European populations from FinnGen database (for IBD) and a published article (for periodontitis), from which independent single nucleotide polymorphisms were selected as instrumental variables. Inverse variance-weighted (IVW), MR-Egger, and weighted median (WM) methods were utilized for MR analysis. Heterogeneity or pleiotropy was detected through Cochran's Q test and MR-Egger intercept, respectively. Outlier was identified with MR-PRESSO (Mendelian Randomization Pleiotropy RESidual Sum and Outlier) and leave-one-out analysis. All statistical analyses were performed with R 4.2.1 and the packages of TwoSampleMR version 0.5.6.

Results

Genetic prediction showed that periodontitis was the risk factor of UC (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.01-1.26; P = .027), rather than of CD (OR, 0.92; 95% CI, 0.74-1.15; P = .456) and IBD (OR, 0.96; 95% CI, 0.81-1.13; P = .619). To the contrary, CD, not UC or IBD, resulted in exacerbating periodontitis in terms of the results of the IVW (OR, 1.09; 95% CI, 1.01-1.17; P = .021) and WM (OR, 1.10; 95% CI, 1.01-1.20; P = .030) methods. Heterogeneity or pleiotropy was acceptable.

Conclusions

Our results indicated that CD was the risk factor for periodontitis; conversely, periodontitis was responsible for the exacerbation of UC, enhancing the existence of mouth-gut axis. Patients with UC should pay more attention to periodontal health, while patients with periodontitis should actively pay close heed to intestinal health.

SUBMITTER: Qing X 

PROVIDER: S-EPMC11291616 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Causal Association Analysis of Periodontitis and Inflammatory Bowel Disease: A Bidirectional Mendelian Randomization Study.

Qing Xiangli X   Zhang Chenhui C   Zhong Zhuotai Z   Zhang Tao T   Wang Lin L   Fang Shuangshuang S   Jiang Tianyuan T   Luo Xiaoying X   Yang Yang Y   Song Gengqing G   Wei Wei W  

Inflammatory bowel diseases 20240801 8


<h4>Background</h4>Periodontitis has been reported to be associated with inflammatory bowel disease (IBD), including ulcerative colitis (UC), and Crohn's disease (CD). However, the causality of these 2 diseases remains unclear. We conducted bidirectional Mendelian randomization (MR) to investigate the causal relationship between periodontitis and IBD.<h4>Methods</h4>We obtained the genome-wide association study (GWAS) summary data of European populations from FinnGen database (for IBD) and a pub  ...[more]

Similar Datasets

| S-EPMC8159074 | biostudies-literature
| S-EPMC9845610 | biostudies-literature
| S-EPMC9226443 | biostudies-literature
| S-EPMC10836255 | biostudies-literature
| S-EPMC11349681 | biostudies-literature
| S-EPMC9710718 | biostudies-literature
| S-EPMC9909343 | biostudies-literature
| S-EPMC9530974 | biostudies-literature
| S-EPMC11445167 | biostudies-literature
| S-EPMC11300198 | biostudies-literature