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Antimicrobial susceptibility analysis of isepamicin combination treatments in Mycobacterium abscessus species.

ABSTRACT: This study evaluated the antimicrobial potency of the combination of isepamicin (ISP) for Mycobacterium abscessus species (MABS). 34 clinical MABS strains were isolated from clinical samples. Of them, 11 (32.4 %) were M. abscessus subsp. abscessus (Mab), 22 (64.7 %) were M. abscessus subsp. massiliense (Mma), and one (2.9 %) was M. abscessus subsp. bolletii (Mbo). We compared susceptibility to sitafloxacin (STFX)-ISP and clarithromycin (CLR)-ISP combinations with those of the antimicrobial agents alone, and synergistic effects were observed in 41.2 % and 17.6 % when treated with STFX-ISP and CLR-ISP. By hierarchical cluster analysis, the isolates divided into treatment-sensitive and treatment-resistant groups. Non-Mma or rough colony isolates were significantly likely to belong to the treatment-sensitive group (p = 0.024, p < 0.001, respectively). These results suggest that the ISP-containing combination could be a new therapeutic strategy for MABS, especially in cases of non-Mma: treatment-refractory subspecies, and rough morphotypes: high-virulence morphotypes.

SUBMITTER: Kato Y 

PROVIDER: S-EPMC11295537 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Antimicrobial susceptibility analysis of isepamicin combination treatments in <i>Mycobacterium abscessus</i> species.

Kato Yukari Y   Ihara Hiroaki H   Takei Satomi S   Nakamura Ayako A   Fujimoto Yuichi Y   Handoh Tetsuya T   Kurokawa Kana K   Arai Yuta Y   Shibayama Kohei K   Sumiyoshi Issei I   Ochi Yusuke Y   Watanabe Junko J   Hoshi Kazuaki K   Misawa Shigeki S   Togo Shinsaku S   Naito Toshio T   Tabe Yoko Y   Miida Takashi T   Takahashi Kazuhisa K  

Journal of clinical tuberculosis and other mycobacterial diseases 20240715

This study evaluated the antimicrobial potency of the combination of isepamicin (ISP) for <i>Mycobacterium abscessus</i> species (MABS). 34 clinical MABS strains were isolated from clinical samples. Of them, 11 (32.4 %) were <i>M. abscessus</i> subsp. <i>abscessus</i> (Mab), 22 (64.7 %) were <i>M. abscessus</i> subsp. <i>massiliense</i> (Mma), and one (2.9 %) was <i>M. abscessus</i> subsp. <i>bolletii</i> (Mbo). We compared susceptibility to sitafloxacin (STFX)-ISP and clarithromycin (CLR)-ISP c  ...[more]

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