Dataset Information

Prevalence and factors associated with postoperative sore throat in Ethiopia: A systemic review and meta-analysis, 2023.

ABSTRACT:

Background

Postoperative sore throat (POST) remains a stressful impact of postoperative airway management, and it contributes to mortality and morbidity after general anesthesia. Its pooled prevalence and determinants in Ethiopia have not been fully studied. This study intended to assess the pooled prevalence and risk variables for POST in Ethiopia.

Methods

A systematic review and Meta-analysis were performed as per the recommendation of PRISMA. To evaluate the pooled prevalence and factors significantly associated with POST in Ethiopia, electronic databases were searched till November 30/2023 and publications were chosen based on inclusion criteria. To assess the quality of the included studies, the Joanna Briggs Institute criteria was used. STATA^MP 17 software was used for all data analysis.

Results

Databases were searched for possible research using Medical Subject headings or entries or key phrases. Only 12 articles were included in the final analysis after screening by titles, abstracts, and full text based on the qualifying criteria. The pooled prevalence of POST in Ethiopia is 47.3 %. The determinants of POST in Ethiopia were female sex, repeated attempts at intubation, blood visible on the tip of an endotracheal tube or laryngoscope, prolonged duration of intubation, and using endotracheal intubation over laryngeal mask airway.

Conclusion

In Ethiopia, the overall prevalence of postoperative sore throat is substantial. Prolonged intubation for more than 2 h, using ETT over LMA, Sex being female multiple attempts at intubation, and blood seen on the tip of ETT or Laryngoscope were the determinant factors of POST in Ethiopia.

SUBMITTER: Teshome D

PROVIDER: S-EPMC11298646 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature

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Publications

Prevalence and factors associated with postoperative sore throat in Ethiopia: A systemic review and meta-analysis, 2023.

Teshome Diriba D Fenta Efrem E Mekete Getachew G Getachew Nega N Zurbachew Negesse N Geta Kumlachew K Tiruneh Abebe A Chekol Basazinew B

Preventive medicine reports 20240714

<h4>Background</h4>Postoperative sore throat (POST) remains a stressful impact of postoperative airway management, and it contributes to mortality and morbidity after general anesthesia. Its pooled prevalence and determinants in Ethiopia have not been fully studied. This study intended to assess the pooled prevalence and risk variables for POST in Ethiopia.<h4>Methods</h4>A systematic review and Meta-analysis were performed as per the recommendation of PRISMA. To evaluate the pooled prevalence a ...[more]

PMID: 39104781

Similar Datasets

Project description:Background/aimsAn updated systematic review and meta-analysis was conducted to assess the effect of prophylactic dexamethasone for tracheal intubation of general anesthesia on postoperative sore throat (POST).MethodsComprehensive literature search of databases for randomized controlled trials (RCTs), including Embase, PubMed, and Cochrane Library, which evaluate the effect of prophylactic dexamethasone on POST was conducted. RevMan 5.0 and STATA 12.0 software were used to perform meta-analyses.ResultsFourteen RCTs totaling 1,837 patients were included for analysis. Compared with placebo, a significant reduction in the incidence of POST (OR 0.44, 95% CI 0.33-0.58, P<0.00001), hoarseness (OR 0.42, 95% CI 0.31-0.58, P<0.00001), and postoperative nausea and vomiting (PONV) (OR 0.06, 95% CI 0.03-0.14, P<0.00001) and a comparable incidence of cough (OR 0.59, 95% CI 0.19-1.89, P=0.38) was described in patients receiving dexamethasone, with or without concomitant drugs. Dexamethasone ≥0.2 mg/kg had a statistically greater impact on reducing the incidence of POST than dexamethasone 0.1-0.2 mg/kg, while dexamethasone ≤0.1 mg/kg did not. Dexamethasone was as effective as other drugs such as ondansetron, magnesium sulfate, ketamine gargle, betamethasone gel, and ketorolac for reducing POST (OR 0.70, 95% CI 0.46-1.07, P=0.10). Dexamethasone plus a different drug was more effective than dexamethasone alone for reducing the incidence of POST at 24 hours (OR 0.40, 95% CI 0.21-0.77, P=0.006). Compared with controls, a statistically higher blood glucose level was the only adverse event during the immediate postoperative period in patients receiving dexamethasone.ConclusionsIntravenous dexamethasone ≥0.2 mg/kg within 30 minutes before or after induction of general anesthesia should be recommended as grade 1A evidence with safety and efficacy in reducing the incidence of POST, hoarseness, and PONV in patients without pregnancy, diabetes mellitus, or contraindications for corticosteroids.

Project description:Objective To estimate the benefits and harms of using corticosteroids as an adjunct treatment for sore throat.Design Systematic review and meta-analysis of randomised control trials.Data sources Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), trial registries up to May 2017, reference lists of eligible trials, related reviews.Study selection Randomised controlled trials of the addition of corticosteroids to standard clinical care for patients aged 5 or older in emergency department and primary care settings with clinical signs of acute tonsillitis, pharyngitis, or the clinical syndrome of sore throat. Trials were included irrespective of language or publication status.Review methods Reviewers identified studies, extracted data, and assessed the quality of the evidence, independently and in duplicate. A parallel guideline committee (BMJ Rapid Recommendation) provided input on the design and interpretation of the systematic review, including the selection of outcomes important to patients. Random effects model was used for meta-analyses. Quality of evidence was assessed with the GRADE approach.Results 10 eligible trials enrolled 1426 individuals. Patients who received single low dose corticosteroids (the most common intervention was oral dexamethasone with a maximum dose of 10 mg) were twice as likely to experience pain relief after 24 hours (relative risk 2.2, 95% confidence interval 1.2 to 4.3; risk difference 12.4%; moderate quality evidence) and 1.5 times more likely to have no pain at 48 hours (1.5, 1.3 to 1.8; risk difference 18.3%; high quality). The mean time to onset of pain relief in patients treated with corticosteroids was 4.8 hours earlier (95% confidence interval -1.9 to -7.8; moderate quality) and the mean time to complete resolution of pain was 11.1 hours earlier (-0.4 to -21.8; low quality) than in those treated with placebo. The absolute pain reduction at 24 hours (visual analogue scale 0-10) was greater in patients treated with corticosteroids (mean difference 1.3, 95% confidence interval 0.7 to 1.9; moderate quality). Nine of the 10 trials sought information regarding adverse events. Six studies reported no adverse effects, and three studies reported few adverse events, which were mostly complications related to disease, with a similar incidence in both groups.Conclusion Single low dose corticosteroids can provide pain relief in patients with sore throat, with no increase in serious adverse effects. Included trials did not assess the potential risks of larger cumulative doses in patients with recurrent episodes of acute sore throat.Systematic review registration PROSPERO CRD42017067808.

Project description:BackgroundTopical pharmacological agents typically used to treat postoperative sore throat (POST) after tracheal intubation include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, lidocaine, Glycyrrhiza (licorice), and N-methyl-d-aspartate (NMDA) receptor antagonists (including ketamine and magnesium). However, the optimal prophylactic drug remains elusive.MethodsThe literature published before September 8, 2019 was searched on the PubMed, the Embase, the Web of Science, and the Cochrane Library. Randomized controlled trials (RCTs) covering topical prophylactic medications for patients with POST were included. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used to assess the quality of evidence. The primary outcome is the risk of POST. Combining both direct and indirect evidence, a network meta-analysis was performed to assess odds ratios (ORs) between the topical pharmacological agents and surface under the cumulative ranking (SUCRA) curve for the treatment-based outcomes. This study is registered with PROSPERO, number CRD42020158985.ResultsSixty-two RCTs (at least 73% of which were double blinded) that included a total of 6708 subjects and compared 6 categories of drugs and/or placebos were ultimately enrolled. All preventive interventions except lidocaine were more effective than placebo at the 4 time intervals. Lidocaine (OR: 0.35, 95% credible interval [CrI], 0.16-0.79) has a greater POST preventative intervention effect than the placebo at a time interval of only 2 to 3 hours after surgery. Relative to lidocaine, the risk of POST except 2 to 3 hours was lower for the following treatments: corticosteroids, ketamine, magnesium, NSAIDs, and Glycyrrhiza. The NMDA receptor antagonists studied here included ketamine and magnesium. Magnesium generally demonstrated greater benefit than ketamine at 24 hours postsurgery/extubation (OR: 0.41, 95% CrI, 0.18-0.92). Compared with ketamine, corticosteroids were associated with a reduced risk of POST during the 4 to 6 hours (OR: 0.40, 95% CrI, 0.19-0.83) and 24 hours (OR: 0.34, 95% CrI, 0.16-0.72) time intervals. During the 2 to 3 hours time interval, Glycyrrhiza (OR: 0.38, 95% CrI, 0.15-0.97) was more efficacious than magnesium.ConclusionsOur analysis shows that, among the 6 topical medications studied, lidocaine is not optimal for topical use to prevent POST. Glycyrrhizin, corticosteroids, NSAIDs, and NMDA receptor antagonists (ketamine and magnesium) are associated with a reduced postoperative pharyngeal pain across the 4 postsurgical time intervals studied, all of which can be chosen according to the clinical experience of the anesthesiologists and the patient preferences and are recommended for the reduction of postoperative throat pain.

Dataset Information

Prevalence and factors associated with postoperative sore throat in Ethiopia: A systemic review and meta-analysis, 2023.

Background

Methods

Results

Conclusion

Publications

Prevalence and factors associated with postoperative sore throat in Ethiopia: A systemic review and meta-analysis, 2023.

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