Dataset Information

Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults.

ABSTRACT:

Objectives

Endothelial injury may promote declining lung function. We aimed to investigate in well-treated persons living with HIV (PLWH) whether elevated levels of thrombomodulin (TM) and syndecan-1 (SDC1) are associated with excess lung function decline and worsening dyspnea.

Methods

A prospective cohort study comprising patients from the Copenhagen municipality. We included 698 PLWH with undetectable viral load. Biomarkers and demographics were measured at baseline, spirometry [forced expiratory volume in one second (FEV₁) and forced vital capacity (FVC)] and dyspnea score both at baseline and 2-year follow-up.Both biomarkers were dichotomized at the 3rd quartile. Decline in lung function was estimated using a linear mixed model with patient-specific random effect. Increase in dyspnea score was estimated using a general mixed logistic regression model.

Results

We did not find an association between elevated SDC1 or TM and an excess decline in neither FEV₁: SDC1: 4.5 mL/year (95% CI: -3.9-12.9, p = 0.30), TM: 2.2 mL/year (95% CI: -6.0-10.4, p = 0.60) nor FVC: SDC1: 4.1 mL/year (95% CI: -6.0-14.2, p = 0.42), TM: 1.4 mL/year (95% CI: -8.3-11.1, p = 0.78). A subgroup analysis of never-smokers was consistent with the main analysis.Likewise, we did not find any association between elevated SDC1 and TM and increase in dyspnea score: SDC1: OR 1.43 (95% CI: 0.89-2.30, p = 0.14), TM: OR 1.05 (95% CI: 0.65-1.71, p = 0.26).

Conclusion

We did not find a significant association between elevated biomarkers of endothelial injury and decline in lung function nor dyspnea.

SUBMITTER: Ronn C

PROVIDER: S-EPMC11304346 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Publications

Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults.

Rønn Christian C Knudsen Andreas Dehlbæk AD Arentoft Nicoline Stender NS Thudium Rebekka Faber RF Heidari Safura-Luise SL Sivapalan Pradeesh P Ulrik Charlotte S CS Benfield Thomas T Ostrowski Sisse Rye SR Jensen Jens Ulrik Stæhr JUS Nielsen Susanne D SD

Frontiers in medicine 20240724

<h4>Objectives</h4>Endothelial injury may promote declining lung function. We aimed to investigate in well-treated persons living with HIV (PLWH) whether elevated levels of thrombomodulin (TM) and syndecan-1 (SDC1) are associated with excess lung function decline and worsening dyspnea.<h4>Methods</h4>A prospective cohort study comprising patients from the Copenhagen municipality. We included 698 PLWH with undetectable viral load. Biomarkers and demographics were measured at baseline, spirometry ...[more]

PMID: 39114826

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Dataset Information

Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults.

Objectives

Methods

Results

Conclusion

Publications

Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults.

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