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ABSTRACT: Background and aims
The prevalence of coexistence of HBsAg and anti-HBs in chronic hepatitis B virus (HBV)-infected patients is different between studies. The mutations on the S gene were proved as the cause of this coexistence. This study determined the frequency and factors associated with coexistence of HBsAg and anti-HBs in chronic HBV-infected patients.Methods
This cross-sectional study was conducted at University Medical Center at Ho Chi Minh City, Vietnam, from April 2014 to December 2020. HBeAg, HBsAg, and anti-HBs were measured by chemiluminescent immunoassay. Mutations on the HBV small S gene from amino acids 1-227 were detected using Sanger sequencing on 177 patients.Results
A total of 521 chronic HBV-infected patients were enrolled, including 350 males (62.7%), 17.1% with hepatic fibrosis of ≥ F3 and 9.8% with hepatocellular carcinoma (HCC). The coexistence of HBsAg and anti-HBs was detected in 9.8%, with 17.9% among genotype C compared to 7.4% in genotype B, P = .001. The coexistence group had lower levels of HBsAg titers (P = .052). There were significantly higher rates of coexistence in the group with HCC (19.6% vs 8.7%, P = .013). The existence of point mutations on the major hydrophilic region and the "a" determinant region of HBV was more frequently detected in the HBsAg and anti-HBs coexistence group (P = .043 and P = .008, respectively).Conclusion
The coexistence of HBsAg and anti-HBs was detected more frequently in the HBV genotype C group. The coexistence status was related to lower HBsAg titers, mutations on the major hydrophilic region, and/or the "a" determinant and exposed significant relation with HCC.
SUBMITTER: Thi Cam Huong N
PROVIDER: S-EPMC11307456 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Thi Cam Huong Nguyen N Vu Hoang Anh HA Luong Bac An BA Makram Abdelrahman M AM Elsheikh Randa R Huy Nguyen Tien NT Le Hoa Pham Thi PT
Gastro hep advances 20230131 4
<h4>Background and aims</h4>The prevalence of coexistence of HBsAg and anti-HBs in chronic hepatitis B virus (HBV)-infected patients is different between studies. The mutations on the S gene were proved as the cause of this coexistence. This study determined the frequency and factors associated with coexistence of HBsAg and anti-HBs in chronic HBV-infected patients.<h4>Methods</h4>This cross-sectional study was conducted at University Medical Center at Ho Chi Minh City, Vietnam, from April 2014 ...[more]