Ontology highlight
ABSTRACT:
SUBMITTER: Hou B
PROVIDER: S-EPMC11309952 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Hou Bowen B Shu Min M Liu Chenghao C Du Yunfeng Y Xu Cuicui C Jiang Huijiao H Hou Jun J Chen Xueling X Wang Lianghai L Wu Xiangwei X
Cancer science 20240618 8
RNA-binding proteins can regulate nucleotide metabolism and gene expression. UPF3B regulator of nonsense mediated mRNA decay (UPF3B) exhibits dysfunction in cancers. However, its role in the progression of hepatocellular carcinoma (HCC) is still insufficiently understood. Here, we found that UPF3B was markedly upregulated in HCC samples and associated with adverse prognosis in patients. UPF3B dramatically promoted HCC growth both in vivo and in vitro. Mechanistically, UPF3B was found to bind to ...[more]