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Identification of a novel sequence at the 3' end of the GB virus B genome.

ABSTRACT: GB virus B (GBV-B) is a virus of the family Flaviviridae that infects small primates (Saguinus sp. [tamarins]) and shows similarities to hepatitis C virus (HCV) in genome organization, protein function, tissue tropism, and pathogenicity. This suggests the possibility of using tamarins infected by GBV-B or GBV-B/HCV chimeric viruses as a surrogate animal model of HCV infection. To achieve the construction of such chimeric viruses, it is essential to produce a complete and infectious GBV-B genomic RNA. We have identified a novel sequence at the 3' end of the GBV-B genome and show that it can be arranged in a secondary structure resembling that of the 3' end of the HCV genome, which is known to be essential for infectivity.

SUBMITTER: Sbardellati A

PROVIDER: S-EPMC113113 | biostudies-literature | 1999 Dec

REPOSITORIES: biostudies-literature

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Identification of a novel sequence at the 3' end of the GB virus B genome.

Sbardellati A A Scarselli E E Tomei L L Kekulé A S AS Traboni C C

Journal of virology 19991201 12

GB virus B (GBV-B) is a virus of the family Flaviviridae that infects small primates (Saguinus sp. [tamarins]) and shows similarities to hepatitis C virus (HCV) in genome organization, protein function, tissue tropism, and pathogenicity. This suggests the possibility of using tamarins infected by GBV-B or GBV-B/HCV chimeric viruses as a surrogate animal model of HCV infection. To achieve the construction of such chimeric viruses, it is essential to produce a complete and infectious GBV-B genomic ...[more]

PMID: 10559376

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