Dataset Information

Para-Hydroxycinnamic Acid Mitigates Senescence and Inflammaging in Human Skin Models.

ABSTRACT: Para-hydroxycinnamic acid (pHCA) is one of the most abundant naturally occurring hydroxycinnamic acids, a class of chemistries known for their antioxidant properties. In this study, we evaluated the impact of pHCA on different parameters of skin aging in in vitro skin models after H₂O₂ and UV exposure. These parameters include keratinocyte senescence and differentiation, inflammation, and energy metabolism, as well as the underlying molecular mechanisms. Here we demonstrate that pHCA prevents oxidative stress-induced premature senescence of human primary keratinocytes in both 2D and 3D skin models, while improving clonogenicity in 2D. As aging is linked to inflammation, referred to as inflammaging, we analyzed the release of IL-6, IL-8, and PGE₂, known to be associated with senescence. All of them were downregulated by pHCA in both normal and oxidative stress conditions. Mechanistically, DNA damage induced by oxidative stress is prevented by pHCA, while pHCA also exerts a positive effect on the mitochondrial and glycolytic functions under stress. Altogether, these results highlight the protective effects of pHCA against inflammaging, and importantly, help to elucidate its potential mechanisms of action.

SUBMITTER: Tan CYR

PROVIDER: S-EPMC11312399 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature

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Para-Hydroxycinnamic Acid Mitigates Senescence and Inflammaging in Human Skin Models.

Tan Christina Yan Ru CYR Morenc Malgorzata M Setiawan Melina M Lim Zen Zhi Yan ZZY Soon Ai Ling AL Bierman John C JC Vires Laura L Laughlin Timothy T DeAngelis Yvonne M YM Rovito Holly H Jarrold Bradley B BB Nguyen Thi Quynh Ngoc TQN Lim John Soon Yew JSY Kent Olivia O Määttä Arto A Benham Adam M AM Hawkins Timothy J TJ Lee Xin Er XE Ehrman Matthew C MC Oblong John E JE Dreesen Oliver O Bellanger Sophie S

International journal of molecular sciences 20240726 15

Para-hydroxycinnamic acid (pHCA) is one of the most abundant naturally occurring hydroxycinnamic acids, a class of chemistries known for their antioxidant properties. In this study, we evaluated the impact of pHCA on different parameters of skin aging in in vitro skin models after H2O2 and UV exposure. These parameters include keratinocyte senescence and differentiation, inflammation, and energy metabolism, as well as the underlying molecular mechanisms. Here we demo ...[more]

PMID: 39125721

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Para-Hydroxycinnamic Acid Mitigates Senescence and Inflammaging in Human Skin Models.

Publications

<i>Para</i>-Hydroxycinnamic Acid Mitigates Senescence and Inflammaging in Human Skin Models.

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