Ontology highlight
ABSTRACT:
SUBMITTER: Yang K
PROVIDER: S-EPMC11313794 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20240724 15
As an important class of nitrogen-containing fused heterocyclic compounds, imidazo[1,2-a]pyridines often exhibit significant biological activities, such as analgesic, anticancer, antiosteoporosis, anxiolytic, etc. Using Y(OTf)<sub>3</sub> as a Lewis acid catalyst, a simple and efficient method has been developed for the synthesis of C<sub>3</sub>-alkylated imidazo[1,2-a]pyridines through the three-component aza-Friedel-Crafts reaction of imidazo[1,2-a]pyridines, aldehydes, and amines in the norm ...[more]