Asymmetric Sulfoxidations Catalyzed by Bacterial Flavin-Containing Monooxygenases.
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ABSTRACT:
SUBMITTER: de Gonzalo G
PROVIDER: S-EPMC11313838 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
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Asymmetric Sulfoxidations Catalyzed by Bacterial Flavin-Containing Monooxygenases.
de Gonzalo Gonzalo G Coto-Cid Juan M JM Lončar Nikola N Fraaije Marco W MW
Molecules (Basel, Switzerland) 20240725 15
Flavin-containing monooxygenase from <i>Methylophaga</i> sp. (<i>m</i>FMO) was previously discovered to be a valuable biocatalyst used to convert small amines, such as trimethylamine, and various indoles. As FMOs are also known to act on sulfides, we explored <i>m</i>FMO and some mutants thereof for their ability to convert prochiral aromatic sulfides. We included a newly identified thermostable FMO obtained from the bacterium <i>Nitrincola lacisaponensis</i> (<i>Ni</i>FMO). The FMOs were found ...[more]
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