Ontology highlight
ABSTRACT:
SUBMITTER: Neumaier M
PROVIDER: S-EPMC11314243 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Neumaier Michael M Giesler Sophie S Ast Volker V Roemer Mathis M Voß Timo-Daniel TD Reinz Eileen E Costina Victor V Schmelz Martin M Nürnberg Elina E Nittka Stefanie S Leppä Aino-Maija AM Rudolf Ruediger R Trumpp Andreas A Fuchs Tina T
Science advances 20230901 35
This report demonstrates a novel class of innate immune cells designated "variable immunoreceptor-expressing myeloids" (VIREMs). Using single-cell transcriptomics and genome-wide epigenetic profiling, we establish that VIREMs are myeloid cells unrelated to lymphocytes. We visualize the phenotype of B-VIREMs that are capable of genetically recombining and expressing antibody genes, the exclusive hallmark function of B lymphocytes. These cells, designated B-VIREMs, display monoclonal antibody cell ...[more]