Ontology highlight
ABSTRACT:
SUBMITTER: Shrager JB
PROVIDER: S-EPMC11316201 | biostudies-literature | 2024 Nov
REPOSITORIES: biostudies-literature
Shrager Joseph B JB Randle Ryan R Lee Myung M Ahmed Syed Saadan SS Trope Winston W Lui Natalie N Poultsides George G Liou Doug D Visser Brendan B Norton Jeffrey A JA Nesbit Shannon M SM He Hao H Kapula Ntemena N Wallen Bailey B Fatodu Emmanuel E Sadeghi Cheyenne A CA Konsker Harrison B HB Elliott Irmina I Guenthart Brandon B Backhus Leah L Cooke Roger R Berry Mark M Tang Huibin H
Life science alliance 20240809 11
Reduction in muscle contractile force associated with many clinical conditions incurs serious morbidity and increased mortality. Here, we report the first evidence that JAK inhibition impacts contractile force in normal human muscle. Muscle biopsies were taken from patients who were randomized to receive tofacitinib (n = 16) or placebo (n = 17) for 48 h. Single-fiber contractile force and molecular studies were carried out. The contractile force of individual diaphragm myofibers pooled from the ...[more]