Ontology highlight
ABSTRACT:
SUBMITTER: Paul MW
PROVIDER: S-EPMC11317164 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Paul Maarten W MW Aaron Jesse J Wait Eric E Van Genderen Romano M RM Tyagi Arti A Kabbech Hélène H Smal Ihor I Chew Teng-Leong TL Kanaar Roland R Wyman Claire C
Nucleic acids research 20240801 14
BRCA2 is an essential tumor suppressor protein involved in promoting faithful repair of DNA lesions. The activity of BRCA2 needs to be tuned precisely to be active when and where it is needed. Here, we quantified the spatio-temporal dynamics of BRCA2 in living cells using aberration-corrected multifocal microscopy (acMFM). Using multicolor imaging to identify DNA damage sites, we were able to quantify its dynamic motion patterns in the nucleus and at DNA damage sites. While a large fraction of B ...[more]