Human immunodeficiency virus Env-independent infection of human CD4(-) cells.
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ABSTRACT:
SUBMITTER: Pang S
PROVIDER: S-EPMC113179 | biostudies-literature | 2000 Dec
REPOSITORIES: biostudies-literature
Publications
Human immunodeficiency virus Env-independent infection of human CD4(-) cells.
Pang S S Yu D D An D S DS Baldwin G C GC Xie Y Y Poon B B Chow Y H YH Park N H NH Chen I S IS
Journal of virology 20001201 23
CD4(-) epithelial cells covering mucosal surfaces serve as the primary barrier to prevent human immunodeficiency virus type 1 (HIV-1) infection. We used HIV-1 vectors carrying the enhanced green fluorescent protein gene as a reporter gene to demonstrate that HIV-1 can infect some CD4(-) human epithelial cell lines with low but significant efficiencies. Importantly, HIV-1 infection of these cell lines is independent of HIV-1 envelope proteins. The Env-independent infection of CD4(-) cells by HIV- ...[more]
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