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Electrochemical radical cation aza-Wacker cyclizations.

ABSTRACT: Electrochemical or photochemical single-electron oxidation of bench-stable substrates can generate radical cations that offer unique reactivities as intermediates in various bond-formation processes. Such intermediates can potentially take part in both radical and ionic bond formation; however, the mechanisms involved are complicated and not fully understood. Herein, we report electrochemical radical cation aza-Wacker cyclizations under acidic conditions, which are expected to proceed via radical cations generated by single-electron oxidation of alkenes.

SUBMITTER: Adachi S

PROVIDER: S-EPMC11318630 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Electrochemical radical cation aza-Wacker cyclizations.

Adachi Sota S Okada Yohei Y

Beilstein journal of organic chemistry 20240805

Electrochemical or photochemical single-electron oxidation of bench-stable substrates can generate radical cations that offer unique reactivities as intermediates in various bond-formation processes. Such intermediates can potentially take part in both radical and ionic bond formation; however, the mechanisms involved are complicated and not fully understood. Herein, we report electrochemical radical cation aza-Wacker cyclizations under acidic conditions, which are expected to proceed via radica ...[more]

PMID: 39135656

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