Ontology highlight
ABSTRACT:
SUBMITTER: Patin EC
PROVIDER: S-EPMC11319479 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Patin Emmanuel C EC Nenclares Pablo P Chan Wah Hak Charleen C Dillon Magnus T MT Patrikeev Anton A McLaughlin Martin M Grove Lorna L Foo Shane S Soliman Heba H Barata Joao P JP Marsden Joanna J Baldock Holly H Gkantalis Jim J Roulstone Victoria V Kyula Joan J Burley Amy A Hubbard Lisa L Pedersen Malin M Smith Simon A SA Clancy-Thompson Eleanor E Melcher Alan A AA Ono Masahiro M Rullan Antonio A Harrington Kevin J KJ
Nature communications 20240813 1
The combination of radiotherapy/chemoradiotherapy and immune checkpoint blockade can result in poor outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Here, we show that combining ATR inhibition (ATRi) with radiotherapy (RT) increases the frequency of activated NKG2A<sup>+</sup>PD-1<sup>+</sup> T cells in animal models of HNSCC. Compared with the ATRi/RT treatment regimen alone, the addition of simultaneous NKG2A and PD-L1 blockade to ATRi/RT, in the adjuva ...[more]