Ontology highlight
ABSTRACT:
SUBMITTER: Seidinger A
PROVIDER: S-EPMC11319782 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Seidinger Alexander A Roberts Richard R Bai Yan Y Müller Marion M Pfeil Eva E Matthey Michaela M Rieck Sarah S Alenfelder Judith J König Gabriele M GM Pfeifer Alexander A Kostenis Evi E Klinke Anna A Fleischmann Bernd K BK Wenzel Daniela D
EMBO molecular medicine 20240708 8
Pulmonary arterial hypertension (PAH) is a life-threatening disease with limited survival. Herein, we propose the pharmacological inhibition of Gq proteins as a novel concept to counteract pulmonary vasoconstriction and proliferation/migration of pulmonary artery smooth muscle cells (PASMCs) in PAH. We demonstrate that the specific pan-Gq inhibitor FR900359 (FR) induced a strong vasorelaxation in large and small pulmonary arteries in mouse, pig, and human subjects ex vivo. Vasorelaxation by FR p ...[more]