Ontology highlight
ABSTRACT:
SUBMITTER: Merrigan SD
PROVIDER: S-EPMC11322753 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Merrigan Stephen D SD Kish-Trier Erik E Seegmiller Jesse C JC Johnson-Davis Kamisha L KL
Clinical mass spectrometry (Del Mar, Calif.) 20170101
Mycophenolic acid (MPA) is the active metabolite of the immunosuppressant drug mycophenolate mofetil (MMF), which is commonly prescribed after organ transplantation in conjunction with other immunosuppressants. MMF therapy is monitored to balance therapeutic efficacy with minimizing adverse effects associated with high serum concentrations. A LC-MS/MS method was developed for the quantification of MPA and two additional metabolites, 7-O-mycophenolic acid glucuronide (MPAG) and mycophenolic acid ...[more]