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Intramolecular CH⋯π attraction mediated conformational polymorphism of constrained helical peptides.


ABSTRACT: In nature, biochemical processes depend on polymorphism, a phenomenon by which discrete biomolecules can adopt specific conformations based on their environment. However, it is often difficult to explore the generation mechanism and achieve polymorphic control in artificial supramolecular assembly systems. In this work, we propose a feasible thought for exploring the transformation mechanism of polymorphism in peptide assembly from the perspective of thermodynamic regulation, which enables polymorphic composition to be limited by switchable intramolecular CH⋯π attraction within a certain temperature range. Combined with the density functional theory calculations, we obtained thermodynamic theoretical data supporting the conformation transition and the underlying polymorphism formation principle. Afterward, we properly designed the peptide to alter the probability of CH⋯π attraction occurring. Then, we selectively obtained a homogeneous morphological form with corresponding molecular conformation, which further demonstrated the important role of molecular conformational manipulation in polymorphism selection. This unique template-based strategy developed in this study may provide scientists with an additional line of thought to guide assembly paths in other polymorphic systems.

SUBMITTER: Sun J 

PROVIDER: S-EPMC11322895 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Intramolecular CH⋯π attraction mediated conformational polymorphism of constrained helical peptides.

Sun Jinming J   Tian Zi-You ZY   Liu Jianbo J   Wan Chuan C   Dai Chuan C   Liu Zhihong Z   Xing Yun Y   Wu Yujie Y   Hou Zhanfeng Z   Han Wei W   Yin Feng F   Ye Yuxin Y   Li Zigang Z  

Chemical science 20240809


In nature, biochemical processes depend on polymorphism, a phenomenon by which discrete biomolecules can adopt specific conformations based on their environment. However, it is often difficult to explore the generation mechanism and achieve polymorphic control in artificial supramolecular assembly systems. In this work, we propose a feasible thought for exploring the transformation mechanism of polymorphism in peptide assembly from the perspective of thermodynamic regulation, which enables polym  ...[more]

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