Ontology highlight
ABSTRACT:
SUBMITTER: Mueller Brown K
PROVIDER: S-EPMC11323143 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Mueller Brown Karina K Eutsey Rory R Gazioglu Ozcan O Wang Derek D Vallon Amanda A Rosch Jason W JW Yesilkaya Hasan H Hiller N Luisa NL
Cell reports 20240703 7
The human pathogen Streptococcus pneumoniae (Spn) encodes several cell-cell communication systems, notably multiple members of the Rgg/SHP and the Tpr/Phr families. Until now, members of these diverse communication systems were thought to work independently. Our study reveals that the ABC transporter PptAB and the transmembrane enzyme Eep act as a molecular link between Rgg/SHP and TprA/PhrA systems. We demonstrate that PptAB/Eep activates the Rgg/SHP systems and represses the TprA/PhrA system. ...[more]