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Collagenase and Tyrosinase Inhibitory Compounds from Fish Gut Bacteria Ruegeria atlantica and Pseudoalteromonas neustonica.


ABSTRACT: Ruegeria atlantica and Pseudoalteromonas neustonica are fish gut bacteria that have been isolated from the guts of Pagrus major and Acanthopagrus schlegelii, respectively. A total of 22 compounds (1-22) were isolated from these two bacteria; 16 compounds (1-16) from R. atalantica and 6 compounds (17-22) from P. neustonica. Their chemical structures were elucidated by spectroscopic and spectrometric data analysis and chemical synthesis. Compounds 11 and 13 showed strong collagenase inhibitory activity, with 31.91% and 36.43% at 20 μM, respectively, comparable to or surpassing that of the positive control epigallocatechin gallate (EGCG, 34.66%). Also, compounds 11 and 14 exhibited a mild tyrosinase inhibitory effect of 6.73% and 13.68%, respectively. All of the tested compounds displayed no significant antibacterial activity against Escherichia coli and Bacillus subtilis up to 100 μM. The collagenase- and tyrosinase-inhibitory compound 11, cyclo(l-Pro-d-Leu), was found to be stable under heat (50 °C) and UV light (254 and 365 nm) for up to 6 days. These results indicate that compound 11 could be developed into a cosmeceutical with antiaging effects.

SUBMITTER: Kim J 

PROVIDER: S-EPMC11325404 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Collagenase and Tyrosinase Inhibitory Compounds from Fish Gut Bacteria <i>Ruegeria atlantica</i> and <i>Pseudoalteromonas neustonica</i>.

Kim Jonghwan J   Hwang Su Jung SJ   Lee Gyu Sung GS   Lee Ju Ryeong JR   An Hye In HI   Im Hong Sik HS   Kim Minji M   Lee Sang-Seob SS   Lee Hyo-Jong HJ   Kim Chung Sub CS  

ACS omega 20240729 32


<i>Ruegeria atlantica</i> and <i>Pseudoalteromonas neustonica</i> are fish gut bacteria that have been isolated from the guts of <i>Pagrus major</i> and <i>Acanthopagrus schlegelii</i>, respectively. A total of 22 compounds (<b>1</b>-<b>22</b>) were isolated from these two bacteria; 16 compounds (<b>1</b>-<b>16</b>) from <i>R. atalantica</i> and 6 compounds (<b>17</b>-<b>22</b>) from <i>P. neustonica</i>. Their chemical structures were elucidated by spectroscopic and spectrometric data analysis  ...[more]

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