Ontology highlight
ABSTRACT:
SUBMITTER: Raynal F
PROVIDER: S-EPMC11326123 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Raynal Flavien F Sengupta Kaustav K Plewczynski Dariusz D Aliaga Benoît B Pancaldi Vera V
bioRxiv : the preprint server for biology 20241014
Cancer cells are highly plastic, allowing them to adapt to changing conditions. Genes related to basic cellular processes evolved in ancient species, while more specialized genes appeared later with multicellularity (metazoan genes) or even after mammals evolved. Transcriptomic analyses have shown that ancient genes are up-regulated in cancer, while metazoan-origin genes are inactivated. Despite the importance of these observations, the underlying mechanisms remain unexplored. Here, we study loc ...[more]